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M94A2354.TXT
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1994-10-25
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Document 2354
DOCN M94A2354
TI Possible lethal outcome of primary HIV-infection in children of
nosocomial focus.
DT 9412
AU Sauhat S; Pokrovsky VV; Savkova Z; Tormozova N; Prokopenkova S; Orlov N;
Zhuravliova I; SIU Biopreparat, Rostov-on-Don, Russia.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):323 (abstract no. PC0225). Unique
Identifier : AIDSLINE ICA10/94370221
AB OBJECTIVE: To make clear the reasons of elevated lethality caused by
sepsis, among the children treated in 1988-1989 years at the same
hospital department with another children then becoming seropositive for
HIV as a result of intrahospital infection. METHODS: Risk of
HIV-infection and clinical disease symptoms were evaluated by special
computer program in 14 infants. 2-10 months old, preferably with
diarrhea diagnosis (9 persons), who were dead at infectional department
of Shahty town hospital in the period of intrahospital spread of
HIV-infection, but were not tested for HIV-antibodies. RESULTS: It was
shown, that died children who were at hospital at the same time with
proposed sources of HIV, had got intravenous injections and other
invasive manipulations respectively 1,9 and 1.2 times more. then
HIF-infected ones, and also in 6 and 3 times respectively more than
children appeared to be noninfected. I.e., died children were exposed of
high risk of HIV-infectioning. Possible participating of 3 children
before lethal outcome in epidemic process as the sources of causative
agent was estimated for 9 children being then revealed as HIV-infected
ones. At 2-12 weeks from the beginning of primary hospitalization
clinical picture was accompanied by enhancement of fever (in 13
children), by intensification of diarrhea (in 14), hepatosplenomegaly
(in 14). At blood laboratory tests leuco- and erythropenia were founded
in 14 children, thrombocytopenia--in 7 ones. Fatal outcome was happened
2-12 weeks after indicated symptoms appearence, in spite of
antibacterial and detoxicative therapy. DISCUSSION AND CONCLUSIONS:
Lethal outcomes of children who was undergoed HIV-infection risk in the
nosocomial focus, can be caused by HIV-infection. though there is no
data about lethal outcomes of primary stage of HIV-infection in
literature. The death of these children was explaned by small age and
HIV-infection addition to the basic disease being the reason of
hospitalisation.
DE AIDS-Related Opportunistic Infections/*MORTALITY/TRANSMISSION Cross
Infection/*MORTALITY/TRANSMISSION Diarrhea, Infantile/MORTALITY
Equipment Contamination Female Hospital Mortality Human HIV
Infections/*MORTALITY/TRANSMISSION HIV
Seropositivity/MORTALITY/TRANSMISSION Infant Male Risk Factors
Russia/EPIDEMIOLOGY Survival Rate MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).